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. Newman, Sharlene; Malaia, Evie; Seo, Roy 2014-04-01 The impact of handedness on language processing has been studied extensively and the results indicate that there is a relationship between the two variables; however, the nature of the relationship is not at all clear. In the current study we explored degree of handedness (DH) opposed to direction in a group of right-handed individuals. FMRI was used to explore the impact of DH on the sentence comprehension network. The results revealed that during sentence comprehension activation in regions linked to semantic memory (e.g., anterior temporal cortex) were modulated by DH. Also, unexpectedly the precuneus/posterior cingulate gyrus which has been linked to episodic memory was also affected by DH. These results extend those reported previously by showing that the neural architecture that supports sentence comprehension is modulated by DH.

More specifically, together the results presented here support the hypothesis proposed by Townsend, Carrithers, and Bever (2001) that DH interacts with the language system and impacts the strategy used during sentence comprehension. Newman, Sharlene; Malaia, Evie; Seo, Roy 2014-01-01 The impact of handedness on language processing has been studied extensively and the results indicate that there is a relationship between the two variables; however, the nature of the relationship is not at all clear. In the current study we explored degree of handedness (DH) opposed to direction in a group of right-handed individuals. FMRI was used to explore the impact of DH on the sentence comprehension network. The results revealed that during sentence comprehension activation in regions linked to semantic memory (e.g., anterior temporal cortex) were modulated by DH.

Also, unexpectedly the precuneus/posterior cingulate gyrus which has been linked to episodic memory was also affected by DH. These results extend those reported previously by showing that the neural architecture that supports sentence comprehension is modulated by DH. More specifically, together the results presented here support the hypothesis proposed by Townsend et al. (2001) that DH interacts with the language system and impacts the strategy used during sentence comprehension. PMID:24607732. Bhupal Dev, P. S.; Mohapatra, Rabindra N.; Zhang, Yongchao 2017-07-01 We show that in a class of non-supersymmetric left-right extensions of the Standard Model (SM), the lightest right-handed neutrino (RHN) is naturally stable and can therefore play the role of thermal Dark Matter (DM) in the Universe for a wide mass range from TeV to PeV.

Our model is based on the gauge group SU(3) c × SU(2) L × SU(2) R × U(1) YL × U(1) YR in which a heavy copy of the SM fermions are introduced and the stability of the RHN DM is guaranteed by an automatic Z 2 symmetry present in the leptonic sector. The active neutrino masses in the model arise from the type-II seesaw mechanism. We find a lower bound on the RHN DM mass of order TeV from relic density constraints, as well as an unitarity upper bound in the multi-TeV to PeV scale, depending on the entropy dilution factor. The RHN DM could be made long-lived by soft-breaking of the Z 2 symmetry and provides a concrete example of decaying DM interpretation of the PeV neutrinos observed at IceCube.

Bhupal; Mohapatra, Rabindra N.; Zhang, Yongchao 2017-05-01 We show that in a class of non-supersymmetric left-right extensions of the Standard Model (SM), the lightest right-handed neutrino (RHN) can play the role of thermal Dark Matter (DM) in the Universe for a wide mass range from TeV to PeV. Our model is based on the gauge group SU(3)c ×SU(2)L ×SU(2)R ×U(1)YL ×U(1)YR in which a heavy copy of the SM fermions is introduced and the stability of the RHN DM is guaranteed by an automatic Z2 symmetry present in the leptonic sector. In such models, the active neutrino masses are obtained via the type-II seesaw mechanism. We find a lower bound on the RHN DM mass of order TeV from relic density constraints, as well as a unitarity upper bound in the multi-TeV to PeV scale, depending on the entropy dilution factor.

The RHN DM could be made long-lived by soft-breaking of the Z2 symmetry and provides a concrete example of decaying DM interpretation of the PeV neutrinos observed at IceCube. Jia, Jingfei; Kim, Hyun K; Hielscher, Andreas H 2015-12-01 It is well known that radiative transfer equation (RTE) provides more accurate tomographic results than its diffusion approximation (DA). However, RTE-based tomographic reconstruction codes have limited applicability in practice due to their high computational cost. In this article, we propose a new efficient method for solving the RTE forward problem with multiple light sources in an all-at-once manner instead of solving it for each source separately.

To this end, we introduce here a novel linear solver called block biconjugate gradient stabilized method (block BiCGStab) that makes full use of the shared information between different right hand sides to accelerate solution convergence. Two parallelized block BiCGStab methods are proposed for additional acceleration under limited threads situation. We evaluate the performance of this algorithm with numerical simulation studies involving the Delta-Eddington approximation to the scattering phase function. The results show that the single threading block RTE solver proposed here reduces computation time by a factor of 1.53 as compared to the traditional sequential solution method and the parallel block solver by a factor of 1.5 as compared to the traditional parallel sequential method.

This block linear solver is, moreover, independent of discretization schemes and preconditioners used; thus further acceleration and higher accuracy can be expected when combined with other existing discretization schemes or preconditioners. Senami, Masato; Takayama, Tsutomu 2009-06-01 We reconsidered leptogenesis scenario from right-handed (s)neutrino produced by the decay of inflaton. Besides the well-investigated case that the neutrino decays instantaneously after the production, leptogenesis is possible if neutrino decays after it dominates the universe. In the latter case, right-handed (s)neutrino can decay either while it is relativistic or after it becomes non-relativistic. Especially, the first case has not been discussed seriously in literatures. Resultant lepton asymmetry and constraints from the gravitino problem are studied in broad parameter region, including all cases of this scenario. It is also shown how this leptogenesis scenario depends on the parameters, the inflaton decay rate (the reheating temperature), the right-handed neutrino mass, the washout parameter, and the constraint from the gravitino problem.

Leptogenesis from relativistic neutrino decay is interesting because both thermal and non-thermal gravitino problems can be relaxed. Zeile, William L; Zhang, Fangliang; Dickinson, Richard B; Purich, Daniel L 2005-02-01 Listeria monocytogenes forms right-handed helical rocket tail trajectories during actin-based motility in cell-free extracts, and this stereochemical feature is consistent with actoclampin's affinity-modulated, clamped-filament elongation model Dickinson and Purich, 2002: Biophys J 82:605-617. In that mechanism, right-handed torque is generated by an end-tracking molecular motor, each comprised of a filament barbed end and clamping protein that processively traces the right-handed helix of its filament partner. By contrast, torque is not a predicted property of those models (e.g., elastic propulsion, elastic Brownian ratchet, tethered ratchet, and insertional polymerization models) requiring filament barbed ends to depart/detach from the motile object's surface during/after each monomer-addition step. Helical trajectories also explain why Listeria undergoes longitudinal-axis rotation on a length-scale matching the helical periodicity of Listeria's rocket tails. Bricscad 13 linux keygen 2017.

Tang, Rixin; Whitwell, Robert L; Goodale, Melvyn A 2014-01-01 Previous research (Whitwell et al. In Exp Brain Res 188:603-611, 2008; Whitwell and Goodale in Exp Brain Res 194:619-629, 2009) has shown that trial history, but not anticipatory knowledge about the presence or absence of visual feedback on an upcoming trial, plays a vital role in determining how that feedback is exploited when grasping with the right hand. Nothing is known about how the non-dominant left hand behaves under the same feedback regimens. In present study, therefore, we compared peak grip aperture (PGA) for left- and right-hand grasps executed with and without visual feedback (i.e., closed- vs.

Open-loop conditions) in right-handed individuals under three different trial schedules: the feedback conditions were blocked separately, they were randomly interleaved, or they were alternated. When feedback conditions were blocked, the PGA was much larger for open-loop trials as compared to closed-loop trials, although this difference was more pronounced for right-hand grasps than left-hand grasps. Like Whitwell et al., we found that mixing open- and closed-loop trials together, compared to blocking them separately, homogenized the PGA for open- and closed-loop grasping in the right hand (i.e., the PGAs became smaller on open-loop trials and larger on closed-loop trials). In addition, the PGAs for right-hand grasps were entirely determined by trial history and not by knowledge of whether or n.

. Lin, Hsiang-Wen; Mahady, Gail B.; Popovich, Nicholas G. 2008-01-01 Objectives To describe the conceptual development of a measure for assessing pharmacist knowledge of herbal and dietary supplements. Methods A standardized approach to constructing a multiple-choice competency examination following 8 pre-specified criteria (eg, specifying the target spectrum of herbal and dietary supplements) was used to create an item bank. The quality of each item was evaluated by 5 herbal and dietary supplement content experts based on specific criteria in 3 rounds of review.

Results From 122 initial items, 56 items were retained for the item bank representing 4 content areas: efficacy/effectiveness, safety, drug- supplement interactions, and regulation. The experts tended to agree that the constructed items represented a wide range of difficulty. Conclusion The initial development of a conceptually based item bank/measure of pharmacist herbal and dietary supplement knowledge lays the groundwork for a large-scale validation study. The measure should be useful as a standalone tool and as a component of a knowledge, attitude, and behavior survey for the assessment of pharmacist traits related to herbal and dietary supplements. PMID:18698390.

Levy, Ilana; Attias, Samuel; Ben-Arye, Eran; Goldstein, Lee; Schiff, Elad 2017-04-01 Dietary and herbal supplements (DHS) are widely used in the general population, including during hospitalization. Yet, their potential interactions with prescription drugs have seldom been delineated among inpatients. We aimed to evaluate potentially dangerous interactions of DHS with prescribed medications among inpatients. This was a cross-sectional prospective study involving a cohort of patients hospitalized in 12 departments of a public academic medical center (Bnai Zion Medical Center, Haifa, Israel) from 2009 to 2014.

DHS users were determined via a questionnaire. The Natural Medicine database was used to search for potential DHS-drug interactions for identified DHS, and the clinical significance was evaluated using Lexi-interact online interaction analysis. Medical files were assessed for documentation of DHS use. Univariate and multivariate logistic regression analyses were used to characterize potential risk factors for DHS-drug interactions.

Of 927 patients consenting to answer the questionnaire, 458 (49%) reported DHS use. Of these, 215 (47%) had at least one potential interaction during hospitalization (759 interactions). Of these interactions, 116 (15%) were potentially clinically significant. Older age OR = 1.02 (1.01-1.04), p = 0.002, males OR = 2.11 (1.35-3.29), p = 0.001 and increased number of used DHS OR = 4.28 (2.28-8.03), p.

Nieva, Reynaria; Safavynia, Seyed A; Lee Bishop, Kathy; Laurence, Sperling 2012-01-01 The use of complementary and alternative medicine is common and continues to rise each year, both in the general population and among those with cardiovascular disease. While some supplements may incur risk, particularly when used concomitantly with cardiovascular medications, others have proven benefits. However, supplements such as antioxidants and many herbs can have significant interactions with cardiovascular medications. This study aimed to identify the percentage of patients enrolled in a cardiac rehabilitation program taking herbal, vitamin, and mineral supplements. Electronic and paper charts of 235 patients enrolled in a phase 3 cardiac rehabilitation program were reviewed. Their demographics, medical history, and medications were stratified in an Excel chart, using a large matrix from which data were imported into Matlab for analysis. Custom Matlab programs were created and compiled to determine variables of interest, including percentages of patients with a specific medical condition taking certain supplements.

Sixty-seven percent of patients enrolled in the cardiac rehabilitation program were taking vitamins, with or without minerals (67%, 158 of 235). Multivitamin is the most common form of supplement (51%, 119 of 235), followed by fish oil/omega-3 polyunsaturated fatty acids (27%, 64 of 235). The majority of patients in a phase 3 cardiac rehabilitation program are taking some form of herbal, vitamin, or mineral supplement. Given frequent, complicated patient medication regimens, it is important to educate patients on the potential benefits as well as lack of evidence and possible dangers of supplements. Nieva, Reynaria; Safavynia, Seyed A.; Bishop, Kathy Lee; Sperling, Laurence 2015-01-01 PURPOSE The use of complementary and alternative medicine is common and continues to rise each year, both in the general population and among those with cardiovascular disease.

While some supplements may incur risk, particularly when used concomitantly with cardiovascular medications, others have proven benefits. However, supplements such as antioxidants and many herbs can have significant interactions with cardiovascular medications.

This study aimed to identify the percentage of patients enrolled in a cardiac rehabilitation program taking herbal, vitamin, and mineral supplements. METHODS Electronic and paper charts of 235 patients enrolled in a phase 3 cardiac rehabilitation program were reviewed. Their demographics, medical history, and medications were stratified in an Excel chart, using a large matrix from which data were imported into Matlab for analysis.

Custom Matlab programs were created and compiled to determine variables of interest, including percentages of patients with a specific medical condition taking certain supplements. RESULTS Sixty-seven percent of patients enrolled in the cardiac rehabilitation program were taking vitamins, with or without minerals (67%, 158 of 235). Multivitamin is the most common form of supplement (51%, 119 of 235), followed by fish oil/omega-3 polyunsaturated fatty acids (27%, 64 of 235). CONCLUSION The majority of patients in a phase 3 cardiac rehabilitation program are taking some form of herbal, vitamin, or mineral supplement.

Given frequent, complicated patient medication regimens, it is important to educate patients on the potential benefits as well as lack of evidence and possible dangers of supplements. PMID:22878561. For its scent, flavor, or therapeutic properties. Herbal medicines are one type of dietary supplement. And fresh or dried plants. People use herbal medicines to try to maintain or improve their health.

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Deconinck, Eric; Custers, Deborah; De Beer, Jacques Omer 2015-01-01 The standard procedures for the identification, authentication, and quality control of medicinal plants and herbs are nowadays limited to pure herbal products. No guidelines or procedures, describing the detection or identification of a targeted plant or herb in pharmaceutical preparations or dietary supplements, can be found.

In these products the targeted plant is often present together with other components of herbal or synthetic origin. This chapter describes a strategy for the fast development of a chromatographic fingerprint approach that allows the identification of a targeted plant in herbal preparations and dietary supplements. The strategy consists of a standard chromatographic gradient that is tested for the targeted plant with different extraction solvents and different mobile phases. From the results obtained, the optimal fingerprint is selected.

Subsequently the samples are analyzed according to the selected methodological parameters, and the obtained fingerprints can be compared with the one obtained for the pure herbal product or a standard preparation. Calculation of the dissimilarity between these fingerprints will result in a probability of presence of the targeted plant. Optionally mass spectrometry can be used to improve specificity, to confirm identification, or to identify molecules with a potential medicinal or antioxidant activity.

Mathon, Caroline; Ankli, Anita; Reich, Eike; Bieri, Stefan; Christen, Philippe 2014-01-01 The adulteration of herbal supplements is of growing importance, especially when they contain undeclared compounds like sibutramine that are unsafe drugs. Sibutramine was withdrawn from US and European markets in 2010.

In this study, an HPTLC-UV densitometric method was developed for the quantification of sibutramine in herbal diet foods. Sample extracts were directly applied onto HPTLC silica gel plates and separated with a mobile phase made of a toluene-methanol mixture. Sibutramine was quantified at 225 nm and its unequivocal identification was confirmed by MS using a TLC-MS interface.

During two surveys, 52 weight loss supplements obtained via the Internet were screened. Half of those were adulterated with sibutramine at amounts reaching up to 35 mg per capsule. The results of this validated HPTLC method were compared with those obtained by HPLC-UV and HPLC-MS/MS. The results were not significantly different with the three methods. Araujo, James L; Worman, Howard J 2015-05-06 Despite the widespread use of herbal and dietary supplements (HDS), serious cases of hepatotoxicity have been reported. The popular herbal weight loss supplement, Hydroxycut, has previously been implicated in acute liver injury. Since its introduction, Hydroxycut has undergone successive transformations in its formulation; yet, cases of liver injury have remained an ongoing problem.

We report a case of a 41-year-old Hispanic man who developed acute hepatocellular liver injury with associated nausea, vomiting, jaundice, fatigue and asterixis attributed to the use of a newer formulation of Hydroxycut, SX-7 Clean Sensory. The patient required hospitalisation and improved with supportive therapy. Despite successive transformations in its formulation, potential liver injury appears to remain an ongoing problem with Hydroxycut. Our case illustrates the importance of obtaining a thorough medication history, including HDS, regardless of new or reformulated product marketing efforts. 2015 BMJ Publishing Group Ltd. Worman, Howard J 2015-01-01 Despite the widespread use of herbal and dietary supplements (HDS), serious cases of hepatotoxicity have been reported.

The popular herbal weight loss supplement, Hydroxycut, has previously been implicated in acute liver injury. Since its introduction, Hydroxycut has undergone successive transformations in its formulation; yet, cases of liver injury have remained an ongoing problem. We report a case of a 41-year-old Hispanic man who developed acute hepatocellular liver injury with associated nausea, vomiting, jaundice, fatigue and asterixis attributed to the use of a newer formulation of Hydroxycut, SX-7 Clean Sensory. The patient required hospitalisation and improved with supportive therapy. Despite successive transformations in its formulation, potential liver injury appears to remain an ongoing problem with Hydroxycut. Our case illustrates the importance of obtaining a thorough medication history, including HDS, regardless of new or reformulated product marketing efforts.

PMID:25948859. Snyder, Frank J; Dundas, Mary L; Kirkpatrick, Carol; Neill, Karen S 2009-01-01 Herbal supplements (HS) are used by older persons and are often perceived as safe, although there is limited research that examines why this perception exists. A questionnaire was developed and pilot tested to investigate the use and perceived safety of HS among a convenience sample of 112 adults aged 60 to 92 in southeast Idaho. Fifty-five percent of the participants (n = 62) reported using HS in the past.

Ninety-five percent (n = 59) of those using HS and 75% (n = 37) of nonusers reported they believed most or some HS were safe. Perception of herbal supplement safety was greatly influenced by family and friends, and HS users had a greater perception of safety than nonusers (p.